Home to the Buffalo Sabres of the National Hockey League since 1996, is the largest indoor arena in Western New York, seating 19,070. It replaced the Sabres' former home, Buffalo Memorial Auditorium, where the team played from 1970 to 1996. The venue is also home to the Buffalo Bandits of the National Lacrosse League.

KeyBank Center was previously home to the Canisius Golden Griffins (NCAA), Buffalo Blizzard (NPSL), Buffalo Wings (RHI) and Buffalo Destroyers (AFL).

Originally known as Marine Midland Arena, the venue has since been named HSBC Arena and First Niagara Center.