The Denny Sanford Premier Center is an indoor arena in Sioux Falls, South Dakota. The building is located at 1201 North West Avenue, and is connected to the Sioux Falls Arena and Sioux Falls Convention Center. The Arena's naming rights partners, and largest sponsors, are Sanford Health, First Premier Bank and Premier Bankcard.

Completed in 2014, the arena has a seating capacity of approximately 12,000 spectators and replaces the DakotaDome and Rushmore Plaza Civic Center as the largest indoor venue in South Dakota. The Sioux Falls Arena hosts smaller concerts and events, while the Denny Sanford Premier Center hosts large scale concerts and sporting events.